Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.

Evita G WeagelWeston BurrupRoman KovtunEdwin J VelazquezAbigail M FelstedMichelle H TownsendZachary E EnceErica SuhStephen R PiccoloK Scott WeberRichard A RobisonKim L O'Neill

Published in: Cancer cell international (2018)

Our results show that TK1 localizes on the surface of lung, breast, and colorectal cell lines and is upregulated in malignant tissues and patients compared to healthy tissues and patients. We conclude that TK1 is a potential clinical biomarker for the treatment of lung, breast, and colorectal cancer.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
poor prognosis
risk assessment
human health
protein kinase