SRSF-1 and microvessel density immunohistochemical analysis by semi-automated tissue microarray in prostate cancer patients with diabetes (DIAMOND study).

Giuseppe BroggiArturo Lo GiudiceMarina Di MauroMaria Giovanna AsmundoElisabetta PricocoEliana PiombinoRosario CaltabianoGiuseppe MorgiaGiorgio Ivan Russo

Published in: The Prostate (2021)

PC exhibits widespread heterogeneity in protein expression. In particular, the expressions of the SRSF-1 protein and of the MVD are associated with a worse prognosis and in particular with a greater cell proliferation. These results, although preliminary, may offer new future scientific insights with the aim of highlighting possible genetic alterations linked to a greater expression of SRSF-1 and associated with a worse prognosis.

Keyphrases

prostate cancer
cell proliferation
poor prognosis
binding protein
machine learning
radical prostatectomy
single cell
high throughput
deep learning
genome wide
current status
gene expression
copy number
dna methylation
signaling pathway
pi k akt
data analysis