Leptin promotes proliferation of neonatal mouse stem/progenitor spermatogonia.

Nilgün YersalSevil KöseUtku HorzumSinan ÖzkavukcuKyle E OrwigPetek Korkusuz

Published in: Journal of assisted reproduction and genetics (2020)

The results indicated that leptin supplementation exhibited a dose- and time-dependent proliferative effect on stem/progenitor spermatogonia that was associated with increased expression of ERK1/2 and STAT3 pathways while maintaining their undifferentiated state. This output presents a new agent that may help to expand the stem/progenitor spermatogonia pool from the neonatal testis in order to autotransplant after cancer treatment.

Keyphrases

signaling pathway
cell proliferation
poor prognosis
cell fate
binding protein
long non coding rna