Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma.
Juliana Kern de MoraesVivian Petersen WagnerFlávia Sirotheau Correa PontesGleyson Kleber do Amaral-SilvaCaroline Brunetto de FariasEmily Ferreira Salles PilarLauro Jose GregianinRafael RoeslerPablo Agustin VargasManoela Domingues MartinsPublished in: Oral diseases (2019)
BDNF/TrkB/Akt pathway is significantly increased in malignant cells from OSCC. Moreover, BDNF and Akt represent biomarkers capable to predict a poor prognosis of OSCC patients.