Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma.

Juliana Kern de Moraes Vivian Petersen Wagner Felipe Paiva Fonseca Gleyson Kleber do Amaral-Silva Caroline Brunetto de Farias Emily Ferreira Salles Pilar Lauro Jose Gregianin Rafael Roesler Pablo Agustin Vargas Manoela Domingues Martins

Published in: Oral diseases (2019)

BDNF/TrkB/Akt pathway is significantly increased in malignant cells from OSCC. Moreover, BDNF and Akt represent biomarkers capable to predict a poor prognosis of OSCC patients.

Keyphrases

poor prognosis
signaling pathway
cell proliferation
end stage renal disease
long non coding rna
stress induced
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes
patient reported