Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages.
Stephanie B WallRui LiBrittany ButlerAshley R BurgHubert M TseJennifer L Larson-CaseyA Brent CarterClyde J WrightLynette K RogersTrent E TipplePublished in: Antioxidants (Basel, Switzerland) (2021)
Our data demonstrate that AFN-induced NRF2 activation directly suppresses IL-1β synthesis independent of NFκB and glutathione-mediated antioxidant mechanisms. NRF2 binding to the promoter region of IL1β directly inhibits transcription of the IL1β gene. Collectively, our research suggests that gold compounds elicit NRF2-dependent pulmonary protection by suppressing macrophage-mediated inflammation.