Upregulated expression of Notch1/4 - JAG-1/DLL-1 detected in allergic rhinitis.
Eric HjalmarssonMarianne PetroSusanna Kumlien GeorénOla WinqvistLars-Olaf CardellPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2023)
The present study is the first to demonstrate increased activity in the Notch1/4 - JAG-1/DLL-1 pathways among allergic individuals. Further propagating the importance of Notch signalling in AR and blocking JAG-1 and DLL-1-induced Notch signalling by nasal epithelial cells and Neutrophils are potential targets to reduce allergic airway inflammation.