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Upregulated expression of Notch1/4 - JAG-1/DLL-1 detected in allergic rhinitis.

Eric HjalmarssonMarianne PetroSusanna Kumlien GeorénOla WinqvistLars-Olaf Cardell
Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2023)
The present study is the first to demonstrate increased activity in the Notch1/4 - JAG-1/DLL-1 pathways among allergic individuals. Further propagating the importance of Notch signalling in AR and blocking JAG-1 and DLL-1-induced Notch signalling by nasal epithelial cells and Neutrophils are potential targets to reduce allergic airway inflammation.
Keyphrases
  • allergic rhinitis
  • cell proliferation
  • poor prognosis
  • high glucose
  • drug induced
  • diabetic rats
  • oxidative stress
  • endothelial cells
  • binding protein
  • human health
  • stress induced