Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.
Lamia Aït GhezaliAtousa ArbabianHervé RoudotJean-Philippe BroulandFanny Baran-MarszakEvelyn SalvarisAndrew BoydHans G DrexlerAgnes EnyediRemi LetestuNadine Varin-BlankBela PappPublished in: Journal of experimental & clinical cancer research : CR (2017)
These data show that the calcium pump composition of the ER is concurrent with increased SERCA3 expression during the differentiation of precursor B acute lymphoblastic leukemia cells, that a cross-talk exists between SERCA function and the control of differentiation, and that SERCA3 may constitute an interesting new marker for the study of early B cell phenotype.
Keyphrases
- endoplasmic reticulum
- acute lymphoblastic leukemia
- poor prognosis
- binding protein
- cell cycle arrest
- acute myeloid leukemia
- electronic health record
- allogeneic hematopoietic stem cell transplantation
- machine learning
- long non coding rna
- big data
- cell proliferation
- oxidative stress
- estrogen receptor
- artificial intelligence