Redox-dependent and independent effects of thioredoxin interacting protein.
Xiankun CaoWenxin HeYichuan PangYu CaoAn QinPublished in: Biological chemistry (2021)
Thioredoxin interacting protein (TXNIP) is an important physiological inhibitor of the thioredoxin (TXN) redox system in cells. Regulation of TXNIP expression and/or activity not only plays an important role in redox regulation but also exerts redox-independent physiological effects that exhibit direct pathophysiological consequences including elevated inflammatory response, aberrant glucose metabolism, cellular senescence and apoptosis, cellular immunity, and tumorigenesis. This review provides a brief overview of the current knowledge concerning the redox-dependent and independent roles of TXNIP and its relevance to various disease states. The implications for the therapeutic targeting of TXNIP will also be discussed.
Keyphrases
- nlrp inflammasome
- inflammatory response
- cell cycle arrest
- healthcare
- electron transfer
- oxidative stress
- poor prognosis
- induced apoptosis
- endoplasmic reticulum stress
- binding protein
- protein protein
- cell death
- amino acid
- endothelial cells
- long non coding rna
- small molecule
- toll like receptor
- drug delivery
- signaling pathway
- cancer therapy