The Total Macular Burden of Hyperreflective Foci and the Onset of Persistent Choroidal Hypertransmission Defects in Intermediate AMD.
Alessandro BerniMengxi ShenYuxuan ChengGissel HerreraFarhan HiyaJeremy LiuLiang WangJianqing LiSandy Wenting ZhouOmer TrivizkiNadia K WaheedRobert O'BrienGiovanni GregoriRuikang K WangPhilip J RosenfeldPublished in: American journal of ophthalmology (2024)
The total macular burden of HRF, which includes both the HRF along the RPE and within the retina, is an important predictor of disease progression from iAMD to the onset of persistent hyperTDs and should serve as a key OCT biomarker to select iAMD patients at high risk for disease progression in future clinical trials.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- age related macular degeneration
- clinical trial
- end stage renal disease
- optic nerve
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- risk factors
- randomized controlled trial
- cataract surgery
- patient reported outcomes
- phase iii