An adaptive clinical trial design to identify the target dose of tenecteplase for treatment of acute pulmonary embolism.
Sharon D YeattsLydia D FosterWilliam G BarsanNicholas S BerryClifton W CallawayRoger J LewisBenjamin R SavilleRobert S SilbergleitJeffrey A KlinePublished in: Clinical trials (London, England) (2022)
The proposed design allows evaluation of a greater number of dose levels than would be possible with a non-adaptive design and avoids the need to choose either the continuous or the dichotomized analysis strategy for the primary endpoint.