CTTN Overexpression Confers Cancer Stem Cell-like Properties and Trastuzumab Resistance via DKK-1/WNT Signaling in HER2 Positive Breast Cancer.

So-Jeong MoonHyung-Jun ChoiYoung-Hyeon KyeGa-Young JeongHyung-Yong Kim Jae-Kyung MyungGu Kong

Published in: Cancers (2023)

CTTN activates DKK-1/Wnt/β-catenin signaling to induce trastuzumab resistance. We propose that CTTN is a novel biomarker indicating a poor prognosis and a possible therapeutic target for overcoming trastuzumab resistance.

Keyphrases

poor prognosis
positive breast cancer
epidermal growth factor receptor
long non coding rna
cancer stem cells
metastatic breast cancer
cell proliferation
stem cells
tyrosine kinase