Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives.

Sourav AcharyaSubhashis GhoshMoumita MajiAjmal Roshan Unniram ParambilSandeep SinghArindam Mukherjee

Published in: Chemical communications (Cambridge, England) (2020)

The Ru(ii) complex of an imidazole-mesalazine Schiff base is a unique example showing growth inhibition of 3D-colon cancer stem cell spheroids and bulk colon cancer cells at lower dosage than salinomycin or oxaliplatin. Unlike oxaliplatin which increases the expression of stemness genes (SOX2, KLF4, HES1 and Oct4), these complexes maintain a tight regulation.

Keyphrases

cancer stem cells
stem cells
transcription factor
poor prognosis
blood brain barrier
genome wide
epithelial mesenchymal transition
cell therapy
gene expression
signaling pathway
mesenchymal stem cells
energy transfer
genome wide analysis