Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.

Flor MendezPadma KadiyalaFelipe J NunezStephen CarneyFernando M NunezJessica C GaussRamya RavindranSheeba PawarMarta EdwardsMaría Belén Garcia-FabianiSantiago HaasePedro R LowensteinMaria G Castro

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

This study provides insights into the phenotype and function of the tumor immune microenvironment in a mouse model of brainstem glioma harboring mACVR1. Immune-stimulatory gene therapy targeting the hosts' antitumor immune response inhibits tumor progression and increases MS of mice bearing mACVR1 tumors.

Keyphrases

tyrosine kinase
gene therapy
mouse model
epidermal growth factor receptor
high grade
immune response
multiple sclerosis
stem cells
mass spectrometry
poor prognosis
ms ms
drug delivery
inflammatory response
insulin resistance