Pre-implantation exogenous progesterone and pregnancy in sheep. II. Effects on fetal-placental development and nutrient transporters in late pregnancy.

Katherine M HalloranEmily C HoskinsClaire StenhouseRobyn M MosesKathrin A DunlapM Carey SatterfieldHeewon SeoGregory A JohnsonGuoyao WuFuller W Bazer

Published in: Journal of animal science and biotechnology (2021)

This study revealed that exogenous P4 administered in early pregnancy influenced expression of selected genes for nutrient transporters and the expression of a protein involved in polyamine synthesis on day 125 of pregnancy, suggesting a 'programming' effect of P4 on gene expression that affected the composition of nutrients in fetal-placental fluids.

Keyphrases

gene expression
preterm birth
poor prognosis
pregnancy outcomes
binding protein
dna methylation
genome wide
heavy metals
pregnant women
single cell
small molecule
transcription factor
genome wide analysis