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Control of LINE-1 Expression Maintains Genome Integrity in Germline and Early Embryo Development.

Fabiana Barzotto KohlrauschThalita S BerteliFang WangPaula Andrea NavarroDavid Lawrence Keefe
Published in: Reproductive sciences (Thousand Oaks, Calif.) (2021)
Maintenance of genome integrity in the germline and in preimplantation embryos is crucial for mammalian development. Epigenetic remodeling during primordial germ cell (PGC) and preimplantation embryo development may contribute to genomic instability in these cells, since DNA methylation is an important mechanism to silence retrotransposons. Long interspersed elements 1 (LINE-1 or L1) are the most common autonomous retrotransposons in mammals, corresponding to approximately 17% of the human genome. Retrotransposition events are more frequent in germ cells and in early stages of embryo development compared with somatic cells. It has been shown that L1 activation and expression occurs in germline and is essential for preimplantation development. In this review, we focus on the role of L1 retrotransposon in mouse and human germline and early embryo development and discuss the possible relationship between L1 expression and genomic instability during these stages. Although several studies have addressed L1 expression at different stages of development, the developmental consequences of this expression remain poorly understood. Future research is still needed to highlight the relationship between L1 retrotransposition events and genomic instability during germline and early embryo development.
Keyphrases
  • poor prognosis
  • dna methylation
  • induced apoptosis
  • endothelial cells
  • gene expression
  • copy number
  • binding protein
  • cell cycle arrest
  • skeletal muscle
  • signaling pathway
  • long non coding rna
  • cell death
  • germ cell