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Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease.

Dylan J M BergenQiao TongAnkit ShuklaElis NewhamJan ZethofMischa LundbergRebecca RyanScott E YoultenMonika FryszPeter I CroucherGert FlikRebecca J RichardsonJohn P KempChrissy L HammondJuriaan R Metz
Published in: BMC biology (2022)
We show that scales have a strong osteogenic expression profile comparable to other elements of the dermal skeleton, enriched in genes that favour collagen matrix growth. Despite the many differences between scale and endoskeletal developmental processes, we also show that zebrafish scales express an evolutionarily conserved sub-population of genes that are relevant to human skeletal disease.
Keyphrases
  • endothelial cells
  • genome wide
  • induced pluripotent stem cells
  • transcription factor
  • mesenchymal stem cells
  • pluripotent stem cells
  • bone marrow