The Effect of Chunghyul-Dan on Hyperventilation-Induced Carbon Dioxide Reactivity of the Middle Cerebral Artery in Normal Subjects: A Dose-Dependent Study.
Chul JinSang-Kwan MoonSeung-Yeon ChoSeong-Uk ParkWoo-Sang JungJung-Mi ParkChang-Nam KoKi-Ho ChoSeungwon KwonPublished in: Evidence-based complementary and alternative medicine : eCAM (2017)
Background. This study was conducted to show the prompt effect of chunghyul-dan (CHD) on cerebral hemodynamics in order to provide evidence for its use in stroke prevention. Methods. Hyperventilation-induced CO2 reactivity of the middle cerebral artery was measured in 12 healthy male volunteers (mean age: 26.3 ± 1.1 years) using transcranial Doppler sonography. All subjects were examined before and for 3 hours after administration, with an interval of 1 week between measurements. Results. Compared to baseline, the CO2 reactivity of the middle cerebral artery increased significantly at 2 and 3 hours after the administration of CHD (600 mg and 1200 mg). The mean blood pressure and heart rate did not vary from the baseline values in all groups. Conclusion. These data suggest that CHD administration (especially 600 mg) immediately improves cerebral blood flow.
Keyphrases
- middle cerebral artery
- heart rate
- blood pressure
- internal carotid artery
- cerebral blood flow
- carbon dioxide
- heart rate variability
- high glucose
- diabetic rats
- atrial fibrillation
- oxidative stress
- electronic health record
- randomized controlled trial
- magnetic resonance
- adipose tissue
- machine learning
- skeletal muscle
- clinical trial
- metabolic syndrome
- drug induced
- hypertensive patients
- contrast enhanced