HLA investigation in ICI-induced T1D and isolated ACTH deficiency including meta-analysis.

Mayo OnoMototsugu NagaoHaruki TakeuchiEtsuya FukunagaTomoko NagamineKyoko InagakiIzumi FukudaMasato Iwabu

Published in: European journal of endocrinology (2024)

This study revealed specific HLA signatures associated with ICI-T1D and ICI-IAD. Moreover, HLA-DRB1*15:02-DRB1*06:01, an ICI-IAD-susceptible HLA haplotype, coincides with the ICI-T1D-protective HLA haplotype, suggesting that the presence of DRB1*15:02-DRB1*06:01 may protect against the co-occurrence of T1D in patients with ICI-IAD.

Keyphrases

systematic review
randomized controlled trial
genome wide
single cell
high glucose
oxidative stress
diabetic rats