Hypoxia-induced LncRNA PCGEM1 promotes invasion and metastasis of gastric cancer through regulating SNAI1.

Jun Zhang Haoyi Jin Y Wu Zhi-Chao Zheng Shuai Guo Yue WangD YangX Y MengX XuYan Zhao

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)

Our findings indicated that PCGEM1 is a hypoxia-responsive lncRNA, and contributes to the invasion and metastasis of GC. The potential mechanism is attributed to the regulation of EMT by PCGEM1 and its influence on the expression of SNAI1.

Keyphrases

cell migration
long non coding rna
poor prognosis
long noncoding rna
epithelial mesenchymal transition
endothelial cells
binding protein
human health
signaling pathway
high resolution
gas chromatography
tandem mass spectrometry
solid phase extraction