Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4.

Makito Mizunuma Christophe E Redon Liton Kumar Saha Andy D Tran Anjali Dhall Robin Sebastian Daiki Taniyama Michael J Kruhlak William C Reinhold Naoko Takebe Yves Pommier

Published in: Cancer research communications (2024)

Acetalax and bisacodyl kill cancer cells by causing oncosis following poisoning of the plasma membrane sodium transporter TRPM4 and represent a new therapeutic approach for TNBC.

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