Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase.

Zhendong QiuWenhong DengYupu HongLiang ZhaoMan LiYongjun GuanYingru SuChen ChenQiao ShiJia YuWei Xing Wang

Published in: OncoTargets and therapy (2021)

Knockdown of ACLY and SREBP1 genes inhibit the proliferation, migration, and invasion of colorectal cancer cells, while promoting their apoptosis. Our results identified potential new targets to treat colorectal cancer via lipid synthesis modulation in cancer cells.

Keyphrases

binding protein
fatty acid
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
genome wide
transcription factor
cell death
genome wide identification
bioinformatics analysis
human health