TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway.
Huihui XuSong DunYing GaoJian MingLinping HuiXueshan QiuPublished in: Thoracic cancer (2020)
TMEM107 expression is lower in NSCLC tissues and correlates with poor prognosis TMEM107 inhibits invasion of NSCLC cells TMEM107 inhibits EMT of NSCLC cells Downregulation of TMEM107 activates the Hedgehog signaling pathway Downregulation of TMEM107 promotes EMT and migration in NSCLC by activating the Hedgehog signaling pathway.
Keyphrases
- signaling pathway
- induced apoptosis
- poor prognosis
- small cell lung cancer
- epithelial mesenchymal transition
- advanced non small cell lung cancer
- pi k akt
- cell cycle arrest
- long non coding rna
- brain metastases
- endoplasmic reticulum stress
- cell migration
- oxidative stress
- epidermal growth factor receptor
- binding protein