Alpha-lipoic acid preserves skeletal muscle mass in type 2 diabetic OLETF rats.
Oak-Kee HongJang-Won SonHyuk-Sang KwonSeong-Su LeeSung-Rae KimSoon Jib YooPublished in: Nutrition & metabolism (2018)
ALA treatment preserved mass in the gastrocnemius muscles of OLETF rats. ALA significantly upregulated the AMPK/SIRT1/PGC-1α and AKT/mTOR/p70S6K signaling pathways in OLETF rat skeletal muscle. Therefore, ALA may be a potential therapeutic intervention for skeletal muscle loss in animal models of insulin resistance.
Keyphrases
- skeletal muscle
- insulin resistance
- signaling pathway
- cell proliferation
- high fat diet
- randomized controlled trial
- oxidative stress
- polycystic ovary syndrome
- high fat diet induced
- adipose tissue
- type diabetes
- metabolic syndrome
- epithelial mesenchymal transition
- combination therapy
- weight loss
- replacement therapy
- smoking cessation