Differential regulation of PD-1 and its ligands in allergic asthma.

Kai BratkeL FritzF NokodianK GeißlerK GarbeM LommatzschJ C Virchow

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)

This study shows, for the first time, an association of a low PD-1 expression by circulating CD4+ T cells with high total and specific (against the allergen used for provocation) IgE concentrations in allergic asthma. In addition, we demonstrate a differential regulation of PD-1 ligands on endobronchial DCs after allergen challenge which may favour Th2 inflammation. Therefore, modulating PD-1 ligand-mediated pathways might be a promising target in allergic asthma.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
oxidative stress
poor prognosis
signaling pathway
air pollution
binding protein