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Organophotoredox-Catalyzed Direct C-H Amination of 2H-Indazoles with Amines.

Sukanya NeogiAsim Kumar GhoshKoushik MajhiSadhanendu SamantaGolam KibriyaAlakananda Hajra
Published in: Organic letters (2020)
A general and practical method for the direct C-H amination of 2H-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles, and sulfoximines via organophotoredox-catalyzed oxidative coupling has been disclosed at room temperature under ambient air conditions. Additionally, this protocol is used for free aminated 2H-indazole synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.
Keyphrases
  • room temperature
  • electron transfer
  • ionic liquid
  • randomized controlled trial
  • air pollution
  • particulate matter