Bayesian basket trial design with false-discovery rate control.

Emily C ZaborMichael J KaneSatrajit RoychoudhuryLei NieBrian P Hobbs

Published in: Clinical trials (London, England) (2022)

Selection of the prior exchangeability probability based on calibration and incorporation of false-discovery rate control result in multisource exchangeability model designs with high power to detect promising treatments in the context of phase II basket trials.

Keyphrases

phase ii
clinical trial
open label
small molecule
phase iii
high throughput
placebo controlled
double blind
study protocol
randomized controlled trial
finite element analysis