Association of G protein-coupled receptor 78 with salivary dysfunction in male Sjögren's patients.

Tsutomu TanakaMaria C Guimaro Hiroyuki NakamuraPaola PerezYoungmi JiDrew G MichaelSandra A AfioneChangyu ZhengCorinne GoldsmithWilliam D SwaimAnne Marie Lynge PedersenJohn A Chiorini

Published in: Oral diseases (2023)

GPR78 overexpression can induce apoptosis and salivary gland hypofunction in male mice through lysosomal dysfunction and increased caspase-dependent apoptosis in salivary gland epithelium, which may drive disease in humans.

Keyphrases

oxidative stress
cell death
end stage renal disease
endoplasmic reticulum stress
cell cycle arrest
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
fatty acid
patient reported outcomes
signaling pathway
disease activity
pi k akt