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Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source.

Rebecca L BrocatoHua WuSteven A KwilasLucia M PrincipeMatthew JosleynJoshua ShamblinPadmanabh ChivukulaChristoph BauschThomas LukeEddie J SullivanJay W Hooper
Published in: mBio (2024)
This candidate polyclonal human IgG product was produced using synthetic gene-based vaccines and transgenic cows. Having now gone through cGMP production, GLP safety testing, and efficacy testing in animals, SAB-163 is the world's most advanced anti-hantavirus antibody-based medical countermeasure, aside from convalescent human plasma. Importantly, SAB-163 targets the most prevalent hantaviruses on four continents.
Keyphrases
  • endothelial cells
  • induced pluripotent stem cells
  • healthcare
  • pluripotent stem cells
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  • stem cells
  • dna methylation
  • genome wide
  • cell therapy