TNFα expression by Porphyromonas gingivalis-stimulated macrophages relies on Sirt1 cleavage.

Sai R K MekaTahsin YounisEli ReichJinan ElayyanAshok KumarEmmanuelle MerquiolGalia BlumShira KalmusYonathan H MaatufGeorge BatshonGabriel NussbaumYael Houri-HaddadMona Dvir-Ginzberg

Published in: Journal of periodontal research (2021)

Together, the results suggest that P. gingivalis induces TNFα expression, at least in part, by enhancing cleavage of Sirt1 via a TLR-dependent signaling circuit.

Keyphrases

poor prognosis
rheumatoid arthritis
oxidative stress
ischemia reperfusion injury
dna binding
binding protein
immune response
long non coding rna
transcription factor