The Physiological MicroRNA Landscape in Nipple Aspirate Fluid: Differences and Similarities with Breast Tissue, Breast Milk, Plasma and Serum.
Susana I S PatuleiaCarla H van GilsAngie M Oneto CaoMarije F BakkerPaul J van DiestElsken van der WallCathy B MoelansPublished in: International journal of molecular sciences (2020)
This is the first study to characterize and compare the unique physiological NAF-derived miRNA landscape with the physiological expression pattern in breast tissue, breast milk, plasma and serum. Breast-specific sources did not mutually overlap more than with systemic sources. Given their established role in carcinogenesis, NAF miRNA assessment could be a valuable tool in breast tumor diagnostics.