Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.

Shengfeng ZhanKun WangYu SongShuai LiHuipeng YinRongjin LuoZhiwei LiaoXinghuo WuYukun ZhangCao Yang

Published in: Arthritis research & therapy (2019)

Our findings confirmed that HOTAIR promoted NP cell senescence, apoptosis, and ECM degradation via the activation of the Wnt/β-catenin pathway, while silencing HOTAIR attenuated this degeneration process, indicating a potential therapeutic target against IDD.

Keyphrases

long non coding rna
poor prognosis
cell proliferation
stem cells
oxidative stress
single cell
endoplasmic reticulum stress
dna damage
cell death
cell therapy
endothelial cells
cell cycle arrest
extracellular matrix
human health
stress induced