Beyond Traditional Medicine: EVs-Loaded Hydrogels as a Game Changer in Disease Therapeutics.
Shutong DuXiaohu ZhouBo ZhengPublished in: Gels (Basel, Switzerland) (2024)
Extracellular vesicles (EVs), especially exosomes, have shown great therapeutic potential in the treatment of diseases, as they can target cells or tissues. However, the therapeutic effect of EVs is limited due to the susceptibility of EVs to immune system clearance during transport in vivo. Hydrogels have become an ideal delivery platform for EVs due to their good biocompatibility and porous structure. This article reviews the preparation and application of EVs-loaded hydrogels as a cell-free therapy strategy in the treatment of diseases. The article also discusses the challenges and future outlook of EVs-loaded hydrogels.
Keyphrases
- drug delivery
- wound healing
- tissue engineering
- cell free
- hyaluronic acid
- drug release
- cancer therapy
- extracellular matrix
- randomized controlled trial
- stem cells
- induced apoptosis
- small molecule
- mesenchymal stem cells
- combination therapy
- systematic review
- cell proliferation
- cell cycle arrest
- high resolution
- cell death
- cell therapy
- oxidative stress
- molecularly imprinted
- highly efficient
- circulating tumor cells
- circulating tumor