Design differences and variation in results between randomised trials and non-randomised emulations: meta-analysis of RCT-DUPLICATE data.

Rachel Heyard Leonhard Held Sebastian G Schneeweiss Shirley V Wang

Published in: BMJ medicine (2024)

This analysis suggests that a substantial proportion of the observed variation between results from randomised controlled trials and real world evidence studies can be attributed to differences in design emulation.

Keyphrases

clinical trial
open label
double blind
study protocol
placebo controlled
electronic health record
randomized controlled trial
big data