Adverse drug events caused by three high-risk drug-drug interactions in patients admitted to intensive care units: a multicentre retrospective observational study.

Joanna Ewa KlopotowskaJan-Hendrik LeopoldTinka BakkerIzak Yasrebi-de KomFrouke M EngelaerEvert de JongeEsther K Haspels-HogervorstWalter M van den BerghMaurits H RenesBas T JongHans KieftAndre WieringaStefaan HendriksCedric LauSjoerd H W van BreeHendrick J W LammersPeter C WierengaRob J BosmanVincent M de JongMirjam SlijkhuisEric J F FranssenWytze J VermeijdenJoost MasselinkIlse M PurmerLiesbeth E BosmaMartin HoeksemaElsbeth WesselinkDylan W de LangeNicolette F de KeizerDave A DongelmansAmeen Abu-Hanna

Published in: British journal of clinical pharmacology (2023)

The highly preventable nature and severity of DDI-ADEs, calls for action to optimize ICU patient safety. Use of e-triggers proved to be a promising pre-selection strategy.

Keyphrases

adverse drug
patient safety
intensive care unit
cross sectional
mechanical ventilation
quality improvement
electronic health record
study protocol
clinical trial
emergency department
drug induced
double blind
acute respiratory distress syndrome