Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer.

Shaymaa Bahnassy Hillary S AndrewsLu JinStanley TamDua MobinManasi Balachandran Mircea Podar Matthew D McCoyRobert A BeckmanRebecca B Riggins

Published in: bioRxiv : the preprint server for biology (2023)

The BT474 and MM361 AI-resistant models capture distinct phenotypes of HER2+/ER+ BCa and identify altered lipid metabolism and ferroptosis remodeling as vulnerabilities of this type of ETR BCa.

Keyphrases

endoplasmic reticulum
estrogen receptor
breast cancer cells
cell death
stem cells
fatty acid
bone marrow
cell therapy
smoking cessation
breast cancer risk