IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Zahra NochiHossein PiaPetra Bloms-FunkeIrmgard BoeslOmbretta CaspaniSonya C ChapmanFrancesca FardoBernd GenserMarcus GoetzAnna V KostenkoCaterina LeoneThomas LiAndré MourauxBernhard PelzEsther Pogatzki-ZahnAndreas SchilderErik SchnetterKarin SchubartAlexandre StouffsIrene TraceyIñaki F TroconizAndrea TruiniJohannes Van NielJose Miguel VelaKaty VincentJan VollertVishvarani WanigasekeraMatthias WittayerHatice TankisiNanna Brix FinnerupKeith G PhillipsRolf-Detlef Treede

Published in: Trials (2022)

This trial was registered 25/06/2019 in EudraCT ( 2019-000942-36 ).

Keyphrases

placebo controlled
phase iii
double blind
phase ii
peripheral nerve
study protocol
clinical trial
open label
neuropathic pain
phase ii study
randomized controlled trial
chronic pain
pain management
postoperative pain
transcranial direct current stimulation
locally advanced