IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).
Zahra NochiHossein PiaPetra Bloms-FunkeIrmgard BoeslOmbretta CaspaniSonya C ChapmanFrancesca FardoBernd GenserMarcus GoetzAnna V KostenkoCaterina LeoneThomas LiAndré MourauxBernhard PelzEsther Pogatzki-ZahnAndreas SchilderErik SchnetterKarin SchubartAlexandre StouffsIrene TraceyIñaki F TroconizAndrea TruiniJohannes Van NielJose Miguel VelaKaty VincentJan VollertVishvarani WanigasekeraMatthias WittayerHatice TankisiNanna Brix FinnerupKeith G PhillipsRolf-Detlef TreedePublished in: Trials (2022)
This trial was registered 25/06/2019 in EudraCT ( 2019-000942-36 ).