Genomic insights into virulence, antimicrobial resistance, and adaptation acumen of Escherichia coli isolated from an urban environment.
Poorvi SainiViraj BandsodeAnuradha SinghSuresh Kumar MendemTorsten SemmlerMunirul AlamNiyaz AhmedPublished in: mBio (2024)
isolates aiming to understand the genetic similarities and differences among isolates from different environmental niches and uncover the survival strategies employed by these bacteria to thrive in their surroundings. Our approach involved molecular characterization of environmental samples using PCR-based DNA fingerprinting and subsequent WGS analysis. This multidisciplinary approach is likely to provide valuable insights into the understanding of any potential spill-over to human and animal populations and locales. Investigating these environmental isolates has significant potential for developing epidemiological strategies against transmission and understanding niche-specific evolutionary patterns.
Keyphrases
- antimicrobial resistance
- human health
- escherichia coli
- genetic diversity
- risk assessment
- endothelial cells
- life cycle
- genome wide
- copy number
- staphylococcus aureus
- pseudomonas aeruginosa
- biofilm formation
- single molecule
- gene expression
- pluripotent stem cells
- dna methylation
- cystic fibrosis
- quality improvement
- free survival
- nucleic acid