Circulating Long Non-Coding RNA GAS5: A Non-Invasive Molecular Marker for Prognosis, Response to Treatment and Survival in Non-Small Cell Lung Cancer.
Majed Al MourgiAhmad A El AskaryAmal F GharibRajab AlzahraniHamsa Jameel BanjerWael H ElsawyAbd El-Rahman Al GhamdiNermin RaafatPublished in: Cancer investigation (2021)
Circulating long non-coding RNAs (lncRNA) are dysregulated in several diseases, especially cancers, e.g. non-small-cell lung cancer (NSCLC). Of specific notice in this regard is growth arrest-specific 5 gene (lncRNA GAS5), which is principally recognised as a tumor suppressor gene in numerous cancers. Functionally, GAS5 is involved in arresting cellular growth and induction of apoptosis. We analysed plasma GAS5 expression by qRT-PCR in 100 patients with NSCLC before and after tumour resection surgery. We reported a downregulation of GAS5 expression in NSCLC tissue and plasma, which showed elevation after surgery. Downregulation of GAS5 was associated with poor prognosis of NSCLC patients.
Keyphrases
- long non coding rna
- poor prognosis
- small cell lung cancer
- room temperature
- advanced non small cell lung cancer
- carbon dioxide
- cell proliferation
- signaling pathway
- end stage renal disease
- ejection fraction
- copy number
- newly diagnosed
- minimally invasive
- brain metastases
- prognostic factors
- chronic kidney disease
- dna methylation
- coronary artery disease
- combination therapy
- peritoneal dialysis
- percutaneous coronary intervention
- coronary artery bypass