Immunological Correlates of Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma.

Alice TzengC Marcela Diaz-MonteroPatricia A RaymanJin S KimPaul G PavicicJames H FinkePedro C BarataMarcelo LamenzaSarah DevonshireKim SchachHamid EmamekhooMarc S ErnstoffChristopher J HoimesBrian I RiniJorge A GarciaTimothy D GilliganMoshe C OrnsteinPetros D Grivas

Published in: Targeted oncology (2019)

Treatment with ICI correlated with distinct changes in PD1/PDL1-expressing peripheral immune cell subsets, which may predict objective response to ICI. Further studies are required to validate immune molecular expression as a prognostic and/or predictive biomarker for long-term outcomes in mUC.

Keyphrases

poor prognosis
squamous cell carcinoma
small cell lung cancer
binding protein
single molecule
long non coding rna