In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study.
Sanhita SinharayTsang-Wei TuZsofia I KovacsWilliam Schreiber-StainthorpMaggie SundbyXiang ZhangGeorgios Z PapadakisWilliam C ReidJoseph A FrankDima A HammoudPublished in: Journal of neuroinflammation (2019)
Using [18F]DPA-714 PET, we documented in vivo neuroinflammatory changes in association with pFUS+MB. Our protocol (utilizing PCD feedback to minimize damage) resulted in neuroinflammation visualized 24 h post one sonication. Our findings were supported by immunohistochemistry showing microglial activation and astrocytosis. Experimental sonication parameters intended for BBB disruption should be evaluated for neuroinflammatory sequelae prior to implementation in clinical trials.
Keyphrases
- lipopolysaccharide induced
- lps induced
- clinical trial
- inflammatory response
- positron emission tomography
- pet ct
- computed tomography
- neuropathic pain
- high resolution
- healthcare
- primary care
- blood brain barrier
- randomized controlled trial
- pet imaging
- traumatic brain injury
- oxidative stress
- quality improvement
- spinal cord injury
- mass spectrometry
- photodynamic therapy