Gadolinium enhancement on cranial MRI in multiple sclerosis is age dependent.
Marcus Werner KochJop MostertJamie GreenfieldWei-Qiao LiuLuanne MetzPublished in: Journal of neurology (2020)
Our investigation shows that gadolinium enhancement is strongly associated with age. Since gadolinium enhancement is a marker of inflammatory disease activity, our findings suggest that inflammatory disease activity declines with age, and that IMD treatment may be more beneficial in younger and less useful in older people with MS.
Keyphrases
- disease activity
- multiple sclerosis
- systemic lupus erythematosus
- rheumatoid arthritis
- contrast enhanced
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- magnetic resonance imaging
- oxidative stress
- mass spectrometry
- physical activity
- computed tomography
- magnetic resonance
- community dwelling
- combination therapy
- smoking cessation