Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.

This study suggests a potential role of circulating homocysteine and possibly folate in NAFLD, which calls for future clinical exploration of the possibility of lowering homocysteine levels to prevent NAFLD. Systematic review registration: registered at https://www.crd.york.ac.uk/prospero/ as CRD42021296434.