A Case of Paraphilia with Osteoporosis and Administered with Depot Leuprorelin.
Dohee KimKyoung Min KimMyung Ho LimPublished in: Medicina (Kaunas, Lithuania) (2019)
Paraphilia is a complex psychological and psychiatric disorder that has been difficult to treat. Leuprorelin has been used as one of the therapeutic methods for paraphilia. Leuprorelin administration could change insulin resistance and accelerate bone loss. The case study in this work was a 59-year-old man who visited a hospital with the chief complaints of frotteuristic behaviors in public places, a continuous increase in sexual desire, and sexual molestation behavior that started in 2007. We injected leuprorelin (3.6 mg) intramuscularly every month for this patient with paraphilia and comorbidities of osteoporosis and hyperthyroidism. The clinical global impression (CGI), Sex Addiction Screening Test (SAST), Wilson Sex Fantasy Questionnaire (WSFQ), physical examination, and laboratory tests were performed. After 12 months of leuprorelin injection for paraphilia, we found a significant improvement in abnormal sexual behavior/desire without aggravation of osteoporosis/hyperthyroidism. Gonadotrophin-Releasing Hormone (GnRH) analogs could be used as alternative or supplementary treatment methods for paraphilia with osteoporosis/hyperthyroidism.
Keyphrases
- postmenopausal women
- mental health
- bone mineral density
- bone loss
- insulin resistance
- healthcare
- adipose tissue
- physical activity
- body composition
- cross sectional
- type diabetes
- metabolic syndrome
- high fat diet
- case report
- molecular docking
- depressive symptoms
- adverse drug
- ultrasound guided
- sleep quality
- psychometric properties
- combination therapy
- molecular dynamics simulations