Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway.

Xiaokang WangJianghong LiuZhanxiong XieJiaoyu RaoGengrui XuKaiyuan HuangWenyan LiZijun Yin

Published in: The Journal of pharmacy and pharmacology (2019)

Our research firstly reports the efficacy of CA against RCC cells and elucidates the underlying molecular mechanisms. These findings indicate that CA is a potential agent for treating RCC.

Keyphrases

induced apoptosis
renal cell carcinoma
endothelial cells
cell cycle arrest
protein kinase
induced pluripotent stem cells
endoplasmic reticulum stress
oxidative stress
pluripotent stem cells
signaling pathway
emergency department
cell proliferation
pi k akt
drug induced