Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer's disease.

Michele M ComerotaManasee GedamWen XiongFeng JinLisheng DengMeng C WangJin WangHui Zheng

Published in: Molecular neurodegeneration (2023)

Together, our study provides support that augmenting OEA-mediated lipid signaling may offer therapeutic benefit against aging and AD through modulating lipid metabolism and microglia phagocytosis and clearance.

Keyphrases

mouse model
fatty acid
inflammatory response
cognitive decline
signaling pathway
skeletal muscle
mild cognitive impairment