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Cell Type-specific Adaptive Signaling Responses to KRASG12C Inhibition.

Hitendra S SolankiEric A WelshBin FangVictoria IzumiLancia DarvilleBrandon StoneRyan FranzeseSandip ChavanFumi KinoseDenis ImbodyJohn M KoomenUwe RixEric B Haura
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our phosphoproteomic study identified cell type-adaptive responses to KRASi. Markers and targets associated with ERBB2/3 signaling in epithelial subtype and with FGFR1/AXL signaling in mesenchymal subtype should be considered in patient enrichment schemes with KRASi.
Keyphrases
  • tyrosine kinase
  • stem cells
  • bone marrow