Neuroprotective Effects of Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Extracellular Vesicles in Ischemic Stroke Models.
Gang LuXianwei SuLihong WangChi-Kwan LeungJingye ZhouZhiqiang XiongWuming WangHongbin LiuWai Yee ChanPublished in: Biomedicines (2023)
Our findings provide evidence of the potential neuroprotective effects of hiPS-MSC-derived extracellular vesicles (hiPS-MSC-EVs) in both in vitro and in vivo mouse models of ischemic stroke. These results suggest that hiPS-MSC-EVs may play a role in neurorestoration and offer insights into potential cell-free strategies for addressing cerebral ischemia.
Keyphrases
- cerebral ischemia
- cell free
- subarachnoid hemorrhage
- brain injury
- blood brain barrier
- endothelial cells
- mesenchymal stem cells
- atrial fibrillation
- mouse model
- high glucose
- human health
- diabetic rats
- bone marrow
- circulating tumor
- induced pluripotent stem cells
- stem cells
- oxidative stress
- umbilical cord
- climate change
- pluripotent stem cells
- circulating tumor cells