Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.
Steffen WolfsgruberJosé Luis MolinuevoMichael WagnerCharlotte E TeunissenLorena RamiNina Coll-PadrósFemke H BouwmanRosalinde E R SlotLinda M P WesselmanOliver PetersKatja LutherKatharina BuergerJosef PrillerChristoph LaskeStefan TeipelAnnika SpottkeMichael T HenekaEmrah DüzelAlexander DrzezgaJens WiltfangSietske A M SikkesWiesje M van der FlierFrank Jessennull nullPublished in: Alzheimer's research & therapy (2019)
While heterogeneous frequency of abnormal Aβ42 was partly explained by between-sample differences in age range and APOE status, the additional observation of center effects indicates between-center heterogeneity that may be attributed to different recruitment procedures. These findings highlight the need for the development of harmonized recruitment protocols for SCD case definition in multinational studies to achieve similar enrichment rates of preclinical AD.