Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity.
Elena E TcheknevaMounika U L GoruganthuRoman V UzhachenkoPortia L ThomasAnneliese AntonucciIrina CheknevaMichael KoenigLongzhu PiaoAnwari AkhterMaria Teresa P de AquinoParvathi RanganathanNicholas LongThomas MaglieryAnna ValujskikhJason V EvansRajeswara R ArasadaPierre P MassionDavid P CarboneAnil ShankerMikhail M DikovPublished in: Journal for immunotherapy of cancer (2019)
Our data show the importance of specific expression of Notch ligands on DCs in the regulation of T-cell effector function. Thus, strategies incorporating selectively engineered Notch ligands could provide a novel approach of therapeutics for modulating immunity in various immunosuppressive conditions including cancer.