Evaluation of dose-tapering strategies for intravenous tocilizumab in rheumatoid arthritis patients using model-based pharmacokinetic/pharmacodynamic simulations.

Carla BastidaAlwin D R HuitemaMerel J l'AmiVirginia Ruiz-EsquideGerrit Jan WolbinkRaimon SanmartíDolors Soy

Published in: European journal of clinical pharmacology (2020)

We demonstrated that the TDM-guided strategy using model-based algorithms performed similarly to mild empirical dose-tapering strategies in overall remission/LDA rates but is superior in cost-savings.

Keyphrases

rheumatoid arthritis patients
disease activity
rheumatoid arthritis
systemic lupus erythematosus
machine learning
juvenile idiopathic arthritis
high dose
deep learning
ulcerative colitis